Tiny Bombs in your Blood - The Complement System
Sources:
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One of the key players of our immune system is the complement system. An army of millions and trillions of tiny bombs, which work together in a complex and elegant dance to stop intruders in your body.
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You can now preorder the Kurzgesagt Immune System book! “IMMUNE - A Journey into the Mysterious System That Keeps You Alive”: kgs.link/ImmuneBook IMMUNE is a fascinating and fun journey through your own body, where we’ll be exploring mystery organs, murder universities, your enemies from viruses, bacteria and cancer (and how your immune system might have killed a cancer cell while you were reading the last few sentences) and the incredibly beautiful and amazing parts, cells and systems that keep you alive. After reading it you should not only gain a new appreciation for your own body but also experience disease differently. Also 45 illustrated pages by the Kurzgesagt team make the book very pretty.
Didn’t think you guys would comment here after 1 year
Just came from the last video
@@johnmcrafter4122 same
@@johnmcrafter4122 same
Same
“Many mindless things can do smart things together” Me and the boys
4chan in a nutshell
@@Uyt-m7an no
@@Uyt-m7an no you are a dead meme go away
@@tmlconfirmed5784 lol what
@@Memeshi *twitter in a nutshell
"Imagine being covered in flies. Now imagine them turning into wasps." I'd rather not, thanks.
Bảo Đậu No, I don't think I will.
ok
Meesa don’t like that
Gold experience be like
No
"Many mindless things can do smart together" *APE TOGETHER STRONK*
AHAHAHAHHAHHAHA BRO
YES
yes indeed
*YES*
ooga booga bois unite
It's very difficult to put in words how motivating this is for me as a med student who's lost lots of my initial drive because of my university's covid coping mechanisms. The complementary system was an especially hard lesson for me to understand considering the absurd amount of random letters and numbers I've had to memorize. Really, thank you for sparking the motivation in me again.
Thanks for choosing medecine. Hang in there you are doing something valuable for yourself and for the world.
@@FutureCommentary1 I hope you create a pill the kills viruses, kinda like antibiotics killing bacteria
@@abirdpilguy3211 "fuck is this algebra or some shit"
Superhero: I keep people safe. C3b: hold my C3a
You deserve an award
that's some 4D chess move right there
nice
But isn't the C3a technically the "Bat Signal" for the superhero team called "The Immune System"?
Dude this the most *microscopic* joke I heard and TQ for that
Knowing that I'm basically a perfectly oiled giant moving fortress with thousands of defence mechanisms makes me feel pretty badass
Change thousands to billions.......there even more awesome
Ye but what if your defense mechanism betrays you
that means you have got the AIDS
@@Internetguy_L337_90D A mutiny within the ship = AIDS
😆
Brain: _Send in the nukes._ Heart: But... there's too many innocent cells in the area! There will be millions of casualties! Brain: JUST DO IT!
Wait, what? Why would the heart say that
@@zaytaz9331 It controls the bloodstream and therefore if it has some kind of self-awareness would be associated with what the immune system's doing.
@@TheAdvertisement hmm, yes I guess you're right but I think a cell (helper T cell) would be the brain you said and the heart maybe the dendric cell, I'm still new to biology tho :)
@@zaytaz9331 I wasn't putting that much thought into it.
The hearts job is too pump blood
As a microbiology student with long stressful hours of preparing for immunology exams I can not recommend this enough. It's an amazing video to truly understand the big picture and then learn the proteins involved in it.
are you a UF student?
Kurzgesagt : "Imagine the flies turn into wasps" Bacteria : END ME .
Bacteria: NANI?!
Flies: OMAE WA MOU SHINDEIRU
Wasps: ORA ORA ORA ORA ORA ORA ORA.
Complement system: Oh, we will.
they will
"Imagine being covered in flies again" I'd rather not "Now, imagine them turning into wasps" I'D RATHER NOT
I pictured that in my head and now I want to die
lol
Now the wasps have alerted a bunch of snakes to cover you. A bear drags you off to a nuclear sub (it's a former KGB bear) that dumps you in shark-infested waters. The planktons clear up any remains of you and in turn are swallowed by whales.
🤣😂😂😂🤣🤣🤣🤣
@@jozsefkalmar7054 😃😆😆😂lol
“Complements to the chef” **muffled explosion noises**
As someone who gets quickly lost talking to immunologist, I appreciate your videos. The immune system is so complex to me that when I think I has grasped one concept, there is another figure out, like an onion with infinite payers. I am also very visual, so you have that aspect of learning covered, too. I am interested in reading your book, "Immune: A Journey into the Mysterious System That Keeps You Alive", too. Thank you for also including a family-run business like Powell's City of Books to sell it through.
I ordered the book because I also really want to read it but I've read several reviews complaining that there were like 3 illustrations and it was more like a textbook. In case you were hoping it was more like their videos
@@BeingForeverBroken idk if u have the book already, but i bought it like 6 months ago and it is full of illustrations. Readable, informative and gorgeous, a worth buy!
@@timoteusfeik5851 I do have it now and I agree with the commenters that it's more like a textbook than a picture book, still need to read it to say anything about it, but happy to have it nonetheless!
"Today's sponsor is you" never felt so special in my life before
same. I can't describe why i felt so touched when he said that
same here
Same
Vayne Carudas Solidor I’m watching ads. You’re welcome d(^0^d)
@Vayne Carudas Solidor But by viewing this video, you increased the view count by 1, which increases their income.
Kurzgesagt: "Imagine being covered in flies" Me: "No" Kurzgesagt: "Do it again" Me: "Stop" Kurzgesagt: "W A S P S"
LOL
just makes me think like that Old Spice commercial. "THE FLIES ARE NOW WASPS."
THE GOGGLES DO NOTHING!
9.1M+ people: pls no
**Yeets self in ice water**
POV: You just watched the first episode of IMMUNE, clicked on part two, and are just now realizing this video is from two years ago.
uh- yea ig
Now it’s 4 yrs
Watching these videos have played a major role in getting me interested in the immune system and biomedical science. I am now back here watching this video again as a biomedical science student who has just started studying the immune system at university and these videos are still super helpful, so thanks guys!
"Imagine you are covered in flies" Oh no I don't like this "Imagine you are covered in flies, but now they're wasps" OH NO NO NO
Relatable :D
OH MY GOD!
Then they wasps are Asian giant hornets
Maniquan challenge go
XD XD
"imagine being covered in flies" no thanks. "Now they are wasps" why do you hate us?
I was expecting a third one. "Now imagine the wasps are tarantulas."
Then leave this channel to normal people. I know you're trying sound funny but it's stupid, if you can't be grateful for this free education find another channel thanks.
@@alexandersebela370 r/whoooosh
@@alexandersebela370 wtf they were joking
Ohh its a little hoovy :3
This series with the immune system is the best one i have come across so far.. This one exactly brought back memories of my uni final year project- which was on the complement system. Great job guys
This playlist started with the Bacterial infection video. The jump in quality and detail of the animation is INCREDIBLE. Even the voice over sounds like he's practiced hard. What a wonderful channel. :)
*imagine you are covered by thousands of flies* No, I don't think I will
It gets worse.
Now imagine those flies turn into wasps
How about worms then?
Pls do this
@@alkureshi a little better but still imma have to decline
Kurzgesagt: "A beautiful example of how many mindless things can do smart things together" *Apes together strong*
Haha I remember 😂😂 that 😂 one 😂
Just like redditors
Awesome...good quote.
Our brain is the same way. Buncha mindless dendrons accepting electric signals...result = our current civilisation
i was thinking the same thing!
Never thought I would be so interested in this stuff!! You make everything interesting, this channel is way too underrated!
This video makes me want to cry at the massively complex such a beautiful system is.
“Imagine being covered by flies” “Oh no” “Now imagine them turning into wasps” “NO”
_panic_
Aw helll nooo!!!
Imagine feeling sympaphy for mindless proteins that trie to kill you every day...
Seriously trying to give me a panic attack
Now *guns*
1:56 So basically, my immune system is powered by Tetris? *...awesome.*
*tetris beatbox*
It’s kind of like that for all proteins. Even more important than the chemical properties are the geometric properties. Our bodies and indeed all living organisms are based on this principle. So yes, you could say that life is a ridiculously over complicated game of Tetris.
John Aldrich Well, life and the universe at large is always trying to make some sort of order out of chaos, and the gameplay of Tetris reflects that. So basically, EVERYTHING is an elaborate game of Tetris.
Looks like doctor Mario wasn't that far off
That's funny boi 😂👌
As a science student, it's absolutely incredible what the human body immune system does so silently as we just live our normal lives.
Complement is one of those topics that I've always been terrified of - this video makes learning about it so much more approachable! Thank you!
"Imagine those thousands of flies turn into wasps" me:(confused screaming)
Man I hate it when that happens. When I get covered by thousands of flies and then they all turn into wasps and start stinging my eyeballs that is. It's super annoying.
THERE IS A STUNNING LACK OF B E E S IN THIS SITUATION! A COUPLE OF BEES SHOULD FIX THIS “AAAAA! MY SITUATION HAS ONLY BE WORSENED BY THE ADDITION OF YET *MORE BEES!*”
Now imagine that they call over their friends to start drilling/boring through your skin...
Moo King STAND STILL! DONT MOVE AS MY BRIEFCASE FULL OF BEES WILL PUT A STOP TO THIS NUISANCE.
U shouldve done it like this me: *confused screaming*
"The complement system does 3 things" 1.Crippling 2.Activating 3. *rip and tear until it's done*
**SOS from Earth**
and the doom guy helps with 3
Lmao holyshit so true. Hmm maybe that's why i feel batter when i listen to doom ost when iwas sick with covid naaa it's probably because of the adrenaline
Doom, but it's Cells At Work
Isn’t there a glory kill in eternal where you break a demons legs/immobilize it and slice it’s em head off with the blade?
Presumably you've already thought of this, but I'm curious to see a video on what happens when the immune system is overwhelmed and the cut becomes majorly infected and you have take antibiotics, that would be really interesting
Most common antibiotics are not bactericidal, but bacteriostatic, this means that they don't kill bacteria, but they prevent them from reproducing. In the end the infection will be taken care of by the immune system but the presence of antibiotics is a massive help. This is also why you don't interrupt your antibiotic treatment as soon as you feel better, if you do, you are allowing the static bacterial population to once again begin reproducing and this will hurt your immune systems chances. Even more because when you feel bad and restart the antibiotics, the bacteria will have adapted and developed resistance! I do agree that this would be a good addition to the immunology series from this channel!
100th loke
Having read your book and then watch this video makes a lot of things that were unclear, clearer. Thanks!
Dude, even 7 minutes of your content felt like 2 minutes. ngl, the video quality is too good to be true!
And 2 minutes feels like 10 years
I was thinking this video was short until I saw your comment and noticed it was actually seven minutes!
1200 hour to make each video, how it couldn’t good
24minute and 30 sec felt like 7 minutes
dam they finally dropped Immune System 2 😳 this is some heat 🔥🔥🔥
Yeah ikr been waiting
Same.
Ayyyyy my man
Bruh
Sethical xd
i love how under every video people always speak in memes. I'm so proud of this community
This is too good to skip!!!! Really love it! Thank you so much for your hard work, this is a really big nice job!
"A beautiful example of how many mindless things can do smart things together." >Any group assignment with my friends.
I wanna meet your friends, my group's motto would be "A beautiful example of how many mindless things can forget what they were supposed to be doing and start blasting Manson at the prudish neighbors"
Or the nerve cells in your brain
Emergence
@ WTF!!! You Just Give A Worst Nuke Code
@ Why? Just... why? You just gave the code for depression, why would you do such a thing?
this video was sponsored by... you :’) thanks man
[happy viewer noise]
@@aromorguy 😂😂😂😂
@@aromorguy lol nice one
why do we die? Why couldn't living things defeat death in their evolution? What's the difference between an old man and a baby? what if we could transfer a person's brain to someone younger than him? if each beginning has an end, can we extend the time between death and right now by transferring our brains to someone else instead of finding immortality?
They also get a lot of free money from the German public TV found. In the end they are a Munich based company.
I only recently found your channel, but I’m so glad I did! Thank you for making such a complex and difficult subject so much easier to understand!! 😊
I enjoyed the complexity of this one a lot more than your other, more general immune system video. You used actual names of the compliment proteins. A great refresher from microbio! Please do more indepth immune system videos like this!
Kurzgesagt: Your body is filled with countless, tiny bombs Airport Security: Say sike right now
American Eggroll haha
To to liberate your body timmy
*your body is filled with countless water bottles
You: has many tiny bombs inside you. Anti-terrorist forces: say sike right now.
Probably the best one I've seen so far🤣🤣🤣😂😂
"tiny bombs in your blood" - Airport security intensifies
Undercover noob lololololol😂😂😂😂😂
Undercover noob i dont get it.
Dustotom2007’s Animations I’m guessing you’re not American, or French or British or whatever. Bombs use to be a problem in airports.
@@okman7933 im italian.
Aslong i know in italy we never had bomb in airports.
OMG!!! I was trying to understand the complement system for the past 2 days. Seriously, what a splendid demonstration!!!!💯 Thank u so much man❤️❤️
Such a good job on this video guys! Thank you!
Bacteria: **Enters human body** C3: I'm about to end this man's whole career
Comment section: *exists* Unoriginal comments: I'm gonna end this man's whole career.
Bih I just created this comment lol Say sike right now
invasive superbug: *exists* C3: wHy WonT yoU DiE
i think you mean: i'm about to end this bacteria's whole career
Never post in the youtube comments again. I'm being serious. You are a disgrace to human kind.
'thousands of them flood away from the site of battle screaming for attention' relatable content wow
mimi2011tiger. A shamefur dispray
ArEa 51
Flashback to pewdiepie vs t series
Or the French
For most of it's history, France was one of the greatest military powers in Europe. Yes, over the last 200 years or so you see a fair amount of French defeats, but you can't say they would ''flood away from the site of battle screaming for attention''.
Thank you for adding more detailed information too, I can use this video for a quick review for my exam as you also added pictures of the activation pathways.
this video is amazing!!! I learned a lot. Thank you
Goes to 7:34 "This video was sponsored by you" *sniffs* you make me cry of joy ;^;
Me like ‘do i have money?’
@@kevinhbrts8423 who knows 👀
Cool a samourtt
@@katherinewatkins1933 ye uwu
Bacteria: "You can't defeat me." C3b: "I know, but he can." *Membrane Attack Complex*
69 likes, but also the part where the membrane attack complex is formed is “C5 Convertase”
@Aiden Charles Arthur Smawfield i see
MAC: "You chose the wrong house, fool."
Technically it’s c7 c6 c8 and c5b
wait so everyone has a mac i feel sorry for pc
I'm a ninth grade student and this is the perfect explanation about the immune system and complementary proteins thank you so much you guys are amazing
Love everything about this video 👌🏾 great job! I appreciate the time and effort that went into this.
I am a doctor and I work with patients with autoimmune disease and thinking about the complement system is a big part of the job. I have NEVER heard a clearer and better explanation about the fundamentals of how this works in my entire training. great job guys! You've gotten yourselves a new Patreon TODAY!!!
vitiligo is also an autoimmune disorder right?
Naveed Aman vitiligo gang vitiligo gang
Amen to that. Where was this when I was struggling to understand immunology back in college?? Lol
The cutesy drawings are aiit too
I have t1 diabetes. An autoimmune disease
"Many mindless things can do a smart thing, together" So...like a government?
I think you got the "smart" part wrong there buddy
A government is many individually smart things failing to cooperate, and thus doing dumb things. Because of this, they're very easy to infect by outside influences looking to get a foothold and usurp the process for personal benefit.
Many "smart" things do dumb things together.
haha, not so good
@Scooters Videos orange man bad
Thank you for coming in my life , when I was in 11 th standard I took science and had lost interest in it , but you helped me get my interest back . I hope you people keep doing this good work
Good video! Thanks for putting this out to the general public.
"This video was sponsored by you." I'm certain I'm in love with a KZhead channel.
Was looking for this comment. People are swarming about the fly scenario.
kurzgesagt is the best (:
As a medical student, complement is one of the the most elaborate and complex topics of Immunology, literally, you just want to sit and cry while studying it, thanks for showing it to the world, getting the most important points in the form you do.
Same here! I took my boards last month, and I only wish I could have used this as a reference.
I love these videos :)
Well, since you seem to have insights on this topic, is there anything you'd want to add to this video that Kurzgesagt had to leave out? Or would you say that this is pretty much a perfect summary of how the Complement System works?
Is the summary accurate? Is there a way to make our complement system more effective?
I dont know, just learning how it works is not thaaaaat hard, not the thing you are going to suffer more while studing
Perfect video! One of many masterpieces, im a vet student and is so much easier to understand the subjects with videos. This is a work of art, im truly amazed to be alive at the same time Kurzgesagt exists. Thank you for all the hard work!
This is an incredibly in-depth video. It was clearly written by someone who is educated in this field
Now i want an RTS-game based on our immune system.
That's what I was thinking too lmao
Those would be great for schools
Thank you, now i need this
Bruh the whole time I was thinking halo wars
I know a game that revolves around being a cell, it has self defense game mechanism but it's about a single cell not the whole immune system. It's called Cell Craft.
Kurzgezagt: "Thank you so much for making this possible." Me: No, thank my Complement system.
Kurzgesagt just used the Compliment system
why don't you compliment your complement system?
@@teochifor2017 It's super effective.
I complement you all
Such an amazing explanation!!! 😍😍😍 Incredible work
Hello, awesome video ! Just continue guys. Never see so compile it together as you describe it.
I'd rather have a compliment system, where all my cells say nice things to me
That is funny
Me too kid
that's funny /2 😄
You look good today!
😂
WHEN I FEEL I AM ALONE THEN I REMEMBER MY IMMUNE SYSTEM IS PROTECTING ME
Always their care of you.
Same
And you can help it whit good diet and exercise :)
*YOU ARE NEVER ALONE...*
WHY ARE YOU SCREAMING THOUGH
Very clear explanation and informative. Thanks
Thank you so much guys for your labor!
Everything starts when c4 is activated. Ops, wrong war
Edo9300 😂
Everything changed when the Fire Nation attacked. Ops, wrong animation
C4 is the most effective way to wipe out all the bacteria and viruses, but the it has pretty bad side effect tho
C4 is an actual explosive. C3 isn’t, sadly.
C4 is one of the safest explosives known to man kind.
_"Many mindless things can do smart things together"_ *_Apes Together Strong_*
Lmao
Lmfao
XD
Big brain time
It’s more like “Proteins together strong” haha
It's always nice seeing these videos, I feel like I get smarter everyday even tho I may forget them in about five minutes.
Excellent! NP student refreshing the immune system. This is the best explanation of a very complex system. Starting advanced pathophysiology this week and after watching your videos and then reading my very confusing textbook cleared the cobwebs.
"many mindless things can do smart things together" apes together strong
N I C E
Axel Bryden lolloololololol
Axel Bryden apes together strong
Jeff Jefferson apes together strong
@@kingcoveryepic ape together strong
"Many mindless things can do smart things together" *me trying to hype up everyone working on the group project*
accurate.
I feel like this should be humanity's slogan. "Stupid things doing smart things together"
In the bacterias defense, they were just hanging out when you clumsily cut yourself on their home and now they're getting covered in "wasps".
Well of course most bacteria are actually harmless, but the ones that are harmful sure can kill you if nothing is done about it. Because our immune systems can not distinguish harmful bacteria from harmless, all they can do is try to leave no one alive.
@@EvilGears so...... the human body is xenophobic for our safety
@@polarbear6479 Not entirely true, Innate Immune Cells can sometimes tell harmless from harmful
Love your videos so much
"Complex and elegant dance" *Proteins float around aimlessly and bump into each other*
HAHAHAHAAHAHAH
Lol
Sounds like a Night out
2:47 And here we can see C3 in its natural habitat, flipping off bacteria to lower the enemy morale. *It's a very successful strategy*
“Go fuck yourself” “Aw man, my feelings”
"Now go away or I shall taunt you a second time!"
Befriend me
Super effective..
Forget C4, C3 is killer!
I watch this a lot and I’ve learned a lot from all of your vids Ty for making these vids :)
you guys are the best, this is actually social work you doing here
Now I'm a biochemist, and I have to say I'm very impressed with how you've simplified it for public consumption without changing anything
Yeah this Chanel is gold
@@papaoso8340 channel*
This is science
They are soooo good !
Joost Channnel?
Every time you feel alone, think that there are billions of cells that are willing to give their lives for you
in reality, it's more akin to you sacrificing yourself to maintain yourself.
@Adromedox How selfish! 😄
@Adromedox who is you? !
Your cells are little tiny you's that are doing their absolute best to live and never giving up. GANBATTE!!
Cells at Work.
I didn't know this thing in detail. Thank you for the information.
This is so amazing, the first video of this channel's that i've come across, and i am usually very stingy with money but Im so sold and ready to pledge to your patreon !!!
“Imagine being covered in thousands of flies” *internal screaming* “Now imagine the turn into wasps” *Confused screaming*
"Now imagine they turn into wasps" *N I G H T M A R E*
“Now imagine they turn into flying ticks” 💀
*nicolas cage's head in a bucket of bees screaming gif
“Now imagine they turn into Horse Flies!”
imagine them fighting in front of your face...
I thought he was going to say skillshare then he said you. This made my day.
This is such a wholesome channel =D
This video was sponsored by you.
Thank you! I love your channel.
I love the animations and shapes of the different complement proteins, it really helps me visualize how complement cleaves with each other like little puzzle pieces
"Imagine being covered in flies" Lol what "Now imagine them turning into wasps" Are you trying to give me a heart attack.
Kurzgesagt needs to stop, they can't give evolution ideas D:
Now imagine KZhead comments without intentionally misusing read-more.
Sheer heart attacku has no weaknessss
hahahahaahhhahahahahahhaaaaahahahsahahaaha
The best description I can give for my reaction is "6:14" Then the wasps was me at 6:17.
*_You expected that I will overlook the improved animations and graphics...?_* OMG Thank you for the likes guys... And obviously hands off to the animators... Great job😉
But it was I DIO?
Yes because they were amazing before too ❤️
My complements to the animators!
Was that a motherfucking!!! JOJO'S reference ?
@@DetectiveLevi HOLY MILK
Honestly better than the way my lecturer explained it... should be all good for my exam on Friday, I know this will come up. Your videos are so helpful Kurzgesagt! Thank you!!!!!!!!!!!!!!! xo
Great editing very helpful thanks
Isn’t it crazy that our body defends itself like a tower defense game
If it was tower defense, the bacteria would have a clear path and our cells would be throwing darts at them
@@heimskr2881 I suppose
@@heimskr2881 monke defeat bloon ooga booga banana good
More like RTS
@@smobasi3367 lol Bloons td
this would be such a cool concept as a game, where you can play on the bacteria/virus side or human side.
Kind of like Spore
now that I think about it that's a decent idea. It would basically be a more complex war game without food or politics. It would have massive armies specialized to take on only certain enemies and if you forget a single part of the immune system like say killer T cells your army falls apart for 1 reason or the other or does worse in the long run like if you did not make any memory T cells. You would like colony survival.
Yeah it can be really interesting. You could make your own bodies from parts and you could make how they change shapes and how they can work together.
It would be really cool
@@zsoltlengyel9085 even that can become politics now lol
Currently binging all of these after being bedridden for 2 days with a high fever and finally starting to feel better. It's so fascinating how my body basically declared war and deployed troops against the virus, as well as setting traps with the complement system. Now I'm hoping my B cells keep making antibodies against whatever virus from hell I just got over. Thanks for the video
I just took your "Immune" book out of the library and I love it!
They should make an rts game based on the immune system, bacteria, and viruses. Like the viruses are slow and sneaky, the bacteria can strike hard and fast but take time to adapt, but the immune system is the reverse of bacteria
Micah Roberts nostalgic af. Would be like a more realistic spore game
theres one where you play AS a bacteria or virus, but its more about infecting the world on a large scale and not about the small battles that occur within bodies
Exactly what I thought
@@ygypt Oh Plague Inc, I had so good times playing it...
Well for highschool biology I did make a simple simulation game of the immune system where the player could do things like add cells of the few types I included and viruses and if you were able to start with a good balance and a bit of luck it was reasonably fun to watch the battle between the b-cells and antibodies against the viruses
Me: *Gets pricked by a needle* My protiens: Avengers, Assemble!
In time you will know how it is like to lose. To feel so desperately that you are right, yet to fail nonetheless.
@@Handsome_Thanos r/wooooooooosh
Bo it should be protein! Assemble
@@sagi-dg8ht No woosh here. Dude saw Avengers and wanted his shit to be seen. Not saying its 200IQ move, but certainly no woosh either
sagi 2019 You are an absolute idiot
love this channel so much