First ‘personalised’ melanoma skin cancer vaccine trial under way in UK | BBC News
A trial of the world’s first “personalised” vaccine against the deadliest form of skin cancer is under way in the UK.
The mRNA vaccine is designed to help patient’s immune systems to recognise and wipe out cancerous melanoma cells.
It is personalised to the individual patient - with its make-up created to match the unique genetic signature of the patient's own tumour, and works by instructing the body to make proteins or antibodies that attack markers or antigens found only on those cancer cells.
Experts in some other countries, including Australia, are also trying it on patients, to gather more evidence and see whether it should be rolled out more widely.
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#Melanoma #BBCNews
Amazing!! I hope this trial is a success
Why bother with the trial? They should just roll it out on the public. Surely there is nothing to lose just having the public involved in a massive clinical trial.
@@dianax266Retard
@@dianax266Blame anti-vaxxers for such skepticism. In a perfect world this drug would have already been approved.
@@dianax266 could even look them in their homes
@@dianax266Fantastic comment! I know exactly where you are coming from 👏
This is great news. my melanoma came back twice (3 surgeries) Then did a year and a half of oral chemo (Tafinlar and Mekinst) followed by a year of immunotherapy, so I've been clear of melanoma for about 3 years. Just getting scanned every 6 months. I hope this new treatment will help all who need it.
Australia has the highest number of skin cancers. We need this so much. My face and self esteem has already been destroyed by skin cancer with more surgery ahead.
Same here. I live in the US & have been burnt to a crisp on numerous occasions in Florida & Arizona but I dunno whats different in Australia (hole in the ozone?) bc I got severe second degree burns, barely missed 3rd degree in several spots, there after just a couple hours. For me to get burned that badly here I’d have to be outside w no sunscreen for 4-5hours midday then go back out the next morning/midday for at least 2 or 3 hours. It was hot when I was there so it wasn’t like I had a false sense of security from cooler weather. The pain was extraordinary & it scarred my back shoulders & neck pretty bad beyond the usual freckles/moles. I probably slept 2hrs at most the next 4-5 nights.
@@LudiCrust. Australia mandated the depop shots!
Might want to give it approx 6-7 years. That would be around the usual length for a trial. Were only 4ish in, and seems to have bumbed more people off than the cure.
Really hope that this treatment could open an opportunity to cure keloids, which are the chronic painful benign skin tumors that have been ignored in the medical field.
I'm high risk for recurrence but this makes it sound like I have to have another melanoma to get one of these shots. My melanoma was removed 4 years ago. I'm considered high risk because both my parents have had melanoma as well
be thankful that some are getting it and your melenoma was fixed.
Dr. Jack Kruse has an interesting hypothesis on melanoma. Mine is gone after less than a month of "treatment", which cost me nothing. I wouldn't advise taking some belligerent neurosurgeons word on how to address such severe conditions of course (and he is quite abrasive, particularly in his podcast with Dr. Huberman of Stanford), but reviewing the published literature he cited led me to try it, as both my 'nomas were on skin areas that never saw sunlight. Prior to this I was unaware that melanoma rates are highest in those of us who rarely get sunlight, tightly correlate to low vit d levels and are rarely expressed in people of any background living near the equator (unless their lives are mostly spent indoors). A pr campaign in the 80s conflated non-lethal basal cell and squamous cell carcinoma (which are associated with excessive sun exposure) to the more dangerous melanoma (which is indeed the opposite) Fitzpatrick Type I here, and I had no idea I could safely tan without burning via pre-9am exposure to sunrise (which has virtually no uv and conditions the skin to safely accept moderate doses of uv-heavy sunlight later in the day.) In addition to treating my spots, my blood pressure dropped significantly to healthy levels (around 10pts systolic), my circadian clock is now spot on and my energy levels are higher than they have been since childhood. Also my need for caffiene decreased and sugar cravings are completely gone. I understand it sounds nuts, but I genuinely want to share what helped me.
Is this different to CAR-T cell therapy, which is also personalised?
Yes. It's different. There is no T cell engineering in this.
Car t theraphy works with t and b lymphocytes. With mRNA you change the DNA
ive had 3 operations to remove melanoma from the back of my head the last 1 was a big removal to get clear skin resulting in a large skin graft being used after 9 cycles of imunitheropy and 3 cycles to go my last x ray showed clear ,,,,, fingers crossed it stays clear i pray a cancer cure is found to remove caner for good for every1
Finally, some good news among the doom and glooms
Agreed
You did here at the start him saying "POTENTIALLY"? I potentially will win the lottery this weekend.
Gotta fail to succeed sometimes. This could be the start of something amazing for alot of people.@dianax266
Still in trial 😢... Only a could be or maybe. Still there is the approval process treatment in the UK 😮
We need it
What could possibly go wrong 🤔
That it won't work and other drugs or chemo/radiation would be required. If it is actually effective then that would be a massive success. Who would want to go through gruelling bouts of chemo if they can have a vaccine instead?
@@hgbnkbggj2915 well based on the last Vax , there may well be problems that are not reversible.
Exactly. 🤔
Thats why it’s a TRIAL, to try if anything goes wrong.
@@petersebela6225yes and now it appears they can still plough on regardless of results.
yeah. no thanks. you can keep it.
01:41, Don't feel bad, you're a pioneer in volunteering to help progress treatment and help other later on. Plus there are possible adverse side effect as with all trials as well so that's why the extra scans and test to see if it's safe and if it works.
No more suncream yeahhh
Looking forward to 2 boosters a day and 7 masks
Isn’t that being greedy.
yeah, what @@davecooper3238 said. Leave some for us, what do you think this is… a pandemic response?
My melanoma was removed from my hip in 1981 at Stoke Manderville Hospital. After 6 months of regular visits, I was pronounced cured, but told to contact the hospital if any symptoms recurred. The didn't. the hospital did a brilliant job.. I hope other patients get treatment as good as I did. Even better news, Jimmy Saville did not show up.
That's okay
What a great advance. Cancer is less frightening with time and discoveries. Bravo to our scientists 🙂
Movie "I Am Legend".....Anyone?
Pokadots on the tie.
Alhumdulillah, a good news ❤
Excellent! Given that melanoma has an inverse correlation with sun exposure (climbing at higher latitudes, higher in blue collar workers, higher in sunscreen users etc) will this product entirely replace the benefits of such exposure or is its job simply to return the metastized melanin back to subcutenous cells and prevent the melanoma from growing? Also will it help with the nonlethal "cosmetic cancers" such as bcc and scc? Finally, will it assist in improving the poor mitochondrial redox melanoma sufferers bear without the need for sun or cold treatments? Very interested.
oops *higher in white collar workers
Amazing! Just had a coworker pass from this in his 30s.
Bet he was vaccinated! They are depopulating with their pharmakeia!
Did he die suddenly of rapid onset cancer?
Please find others cancers treatment for cure...like bowels cancer stomach cancer liver cancer those are become too common now...🙏
CHRIST IS THE ONLY CURE FOR EVERYTHING!
Free myocarditis with every jab.
Not to mention thrombocytopenia!
Not to mention turbo cancers after more of them !
Immune memory is possibly the greatest protection against recurrence of cancer. If a vaccination like this is successful, it would mean that memory cells would be formed so that even if the cancer recurred, the immune system would be effective at killing the cancer before the cancer could become harmful. The challenge is in creating a vaccine against the numerous types of cancers and markers on cells that indicate the cell has become cancerous.
Pretty sure iovance have already done this .
How do we get in touch? I have undiagnosed possible melanoma on my face. My Dr has only seen photographs, but it's changing, scabs up, and reveals dark scar like skin and then scabs up again. I'm scared to go back just to be sneered at again like I'm being stupid
I don't know what your circumstances are, but please seek another doctor/practitioner. I've watched two close family members dismissed by their doctors, only to suffer and die as a result of not seeking a second opinion when their conditions were treatable. Don't let this be your story. Hope you find healing!
are you expecting the BBC to respond to your comment with a contact number for the people conducting the trial? if you have a melanoma i dare say you might need to be a little more proactive then than my man
Going to doctors in this country is completely useless. People keep sayng that the NHS is the best health care system in the world, how delusional, NHS is not the best there are third world countries with better health care than here!
Search for the program online, but first you need a second opinion from a better doctor. This is also your legal right. Don't wait for it.
I would find a different doctor, preferably one who is a dermatologist. Nothing wrong with getting a second opinion. It's your life that's on the line, not the doctor's.
we will need the digital id's for the many more vaccines coming on down the line - tony blair
This is really good news and I hope these trials are successful. My one fear is that the big pharma will get involved in this as a means to boost their already bloated profit margins. I hope this doesn't happen
A decade for facts is too long..but vert good initiative
So a cure for some cancers?
Trust the science guys 👍 Where have i heard that before
This news is very helpful❤❤
Yay
❤
Thank you for the great people from the developed world brings such great technology by putting countless of efforts and resources. It will save lives, save children, save families. Comparing those are still bringing war and deaths to the world, you are the hope of our human being. Thank you. - from a man grew up in a developing country.
bbc, give cure
Imagine the world if, following the united world cooperation against Covid, all countries could continue unite and work together for the greater good, to solve the many other major problems we face as the human race.
Haven’t people learned anything in the last 3 years?
No, that's not what most people do. They go down with the ship and they thank the captain
People? Yes. 'Experts'? They have learned that they can break laws & evade justice.
Protect this man from big pharma
It will need big pharma to bring it to market.
Fingers crossed 🤞 I hope this works as it's got so much potential to help people
Instead of crossing your fingers and relying on their pharmakeia, turn to the Lord Jesus in repentance, for He is the ONLY ANSWER!
They're saying all the right things!
trust the $cientism !
Oh? Vaccines, prevent virus spread, so a vaccine for cancer, stop the spread of the cancer virus? What is right about this?
Hello I Am Legend this is my prediction to the movie to I Am Legend
Nice tie.
Do not take this guys 17000000 already gone after the you know what
Millions die every year. Life is 100% fatal.
@@davecooper3238 it jumped up that much
@@DruidzTV I am glad for the vaccine. A relative & a couple of mates died. Plus one on oxygen in hospital for a couple of weeks. The vaccine came along & that stopped.
@@davecooper3238 THAT'S BECAUSE THE HOSPITALS WERE PAID HANDSOMELY TO PUT PEOPLE ON VENTILATORS AND KILL THEM! HAVE YOU SEEN THE DEAGEL FORECAST FOR MARCH 2025? THE VACCINATED ARE LITERALLY TICKING TIME-BOMBS!
@@davecooper3238 TURBO CANCERS, STROKES AND MYOCARDITIS DIRECTLY RESULTING FROM THE DEATH SHOTS!
Let me guess ... it will be so "safe and effective" that they will mandate it.
Sorry, but no thanks!
At first, I thought it's to do with a court trial 😢
My 5G from the COVID jab still hasn't come on yet, so I'm going to give this one a miss until they work out the bugs
Did your skin become magnetic at least?
I have been given seven Covid jabs. If you count all my jabs starting with Smallpox in the 1940s it must have had a couple of dozen. But what’s 5G. There is a 5G mast nearby but not heard anything about a 5G disease.
You have to pay the subscription fee for that
@@arjaygee lol
This is cool! Some people in this comment section? No so much. Bunch of weirdos.
People get weird when they know they are being deceived.
wHaT coULd pLaUsiBLy gO wRoNg ??!?!?? never forget that the biG pHARmeR lOvEs yOu !!!
It will be nice too get to see a dr
After the past several years, who in their right mind would sign up for this? PEOPLE never learn!
It would seem so.
ever had cancer_ guess not or you wouldn't be here spewing out your gobshytte.
Weren't all the vaccinated people going die? What happened with that?
@@MrKarlhub405 THEY ARE! WAKE UP!
@@edwardbernthal160 WAKE UP! WHAT DO YOU THINK IS CAUSING ALL THIS TURBO CANCER?!? HARDLY ANYONE EVER GOT CANCER IN MY DAY!!
I hate the "jab" description. It sounds like something you don't want to do to your child or yourself.
Why? Because of needle phobia?
😅 It is hard to describe the experience of having a needle suddenly inserted into your arm. I prefer Trudeau's excitement after his vaccinations. 'It, It, It just all of a sudden hits you!'
Id suggest that you don't want to do this to your child or yourself.
A needle is better than death by cancer. Don’t listen to anyone who tells you otherwise.
Here in Americaduh, "jab" is used pejoratively by anti vaxxers
Poison.
Another mRNA.Have they solved all the problems with the last one then?
The problem solves itself, more every week.
😂
I have had 7 of the Covid 19 jabs. Kept me safe so far.
@@davecooper3238 good for you. Though the data seems to suggest otherwise. Good luck
@@curiositycloset2359 The data also suggests that with my co morbidity Covid could have seen me off.
I'm sorry to interrupt this very important message❤ but have you seen Taylor😊?
Whatever the actual result, they will find a way to manipulate the numbers to say it's a resounding success.
An alternate strategy would be to stay out of the sun but that is probably too simple for these rather dull knives.
About time the British fought back against public enemy #1 the Sun 😂
Where’s that advice to check levels and supplement with D3 & Omega3? Nutritional deficiencies wreak havoc… as do diets of inflammatory ultra processed foods.
Ah but they dont make billions of dollars for the drugs companies and no commision to the BBC for pushing drug propaganda, so you wont hear about simple vitamins from the corrupt BBC.
That's hardly relevant here. This is for people who have already been diagnosed. And no amount of healthy eating can prevent certain cancers, some of the causes are genetic, environmental, etc.
@@hgbnkbggj2915 Yes some are caused and accelerated by the very RNA technologoy they are claiming will fix the damage done by it.
A vaccine for Melanoma? Trump will NOT like this.
I had 37 vaxxines last week. Got 12 scheduled for this week. That leaves only 87 more and I'll be up to date till they invent new ones.... Can't wait.
just dangin' up all sorts of elixirs multiple times a day are we bud?
in your case, let's hope that one of the new vaccines combats dumbfounding stupidity
and it was developed 40 years ago and was just sitting on the shelf till now
Yeah, it wouldn't pass tests without an emergency law. That happened in 2020, remember?
@@curiositycloset2359 never watched the video so have no clue but i do know just like every other thing in live it sits on a shelf until enough people have made all there money they can off something then they take it out of the closet
That's sheer nonsense - a baseless assertion. In reality, the technology to develop this has only recently arisen.
@hgbnkbggj2915 are you sure ? I have a question for you Do you think electric cars are new and state of the art ? If you say yes Then you might want to look up the first police vehicle oh and it was not a gas one
@@jacktheripper-hp9tx Yes, I am sure, and I will not dignify your other ridiculous question with an answer. mRNA vaccines are not remotely comparable to previous technologies.
The fascination with jabs is unreal
Don't worry mate, cancer isn't contagious, you can stay away from this jab and keep your cancer
As it should be. Who wouldn't want the chance of a personalised vaccine that could prevent recurrence over chemo/radiation?
Have any of you had a polio vaccine?!?
@@hgbnkbggj2915 makes you wonder why gene therapy was pretty much illegal until 2020. I wonder what changed?
@@austingode you misunderstand the difference between vaccines, and manipulating your dna.
🫨 🙏
If we could invest all the money from the weapons industry into health research...
weapons work pretty good in pop. reduction.
＜榮升刻印店＞有去問鳳鳴高圓，這顆印章前一手的故事？？有神啊！
Yeah lets make more vaccines! Great idea!
Aye, you're the fanny!
@@brettmeikledon't forget to get your booster
Another victory for Poe's Law
Found the anti-vax slopebrain.
It is a great idea. My grandfather was one of 13. Only 7 made it to 21 the rest were lost to infection. Infections that can now be avoided using vaccines.
More religion = more war More science = more progress 🤷♂
Was it religion that made the atomic bomb?
Or does it cause cancer? Who knows!? Only pawns and time will tell. Ive got my popcorn, who's goinna go first, I'll even hold your beer! 🥳🐑💉🐑🔍🥳🕵🐑🤣😂😅🤠🐑🛤🚂🏕
Stops skin cancer, gives you turbo cancer
Oh good, we've got a scientist in the comments who knows all about MRNA! Thank god we didn't waste time and money having actual people who understand cancer and MRNA, we could have just had the emoji king help.
@@aaronwhite1786 go take a look at excess deaths. Scientist lol. I know it hasn't passed clinical trials.
@@curiositycloset2359 Wait, you mean to tell me a measurement of deaths taken shows that a massive global pandemic that killed over 7 million people shows an increase? Have you taken this to the news? The news would love to know this.
Since excess deaths are the number of expected deaths during a specific time period compared to the actual number of observed deaths during that same time period, it’s pretty hard to look at excess deaths until the trials are complete
My conspiracy theory booster has given me immunity from the 200+ extra people a week dying since 2021, so I'll pass on this one thanks😉
They make the frogs gay!!
Jeez you people are depressing. Do not reproduce.
@lovelybitofbugle6762 Carful the BBC comments section is full of people who'd advocate for the frogs to be given access to children in the name of being a drag queen...
Where can I get one of those?
ehh, probably shoudnt matter too much anyway, how many UV rays are you really likely to cop in the 3 or 4 sunny days per year in the UK anyway
It's better to just not eat for a week and let your body do the work naturally.
So I'm guessing the anti-vax crowd will be noisy and not take this? 😃☮
@@NoName88837 Do you have any education in the medical field and vaccine development? No?
@@NoName88837Nobody’s gonna force you to not get cancer lmao what is wrong with u 😂
I’m still here how many injections is it now for you 😂😂😂😂
@@holokyttaja5476do you
You mean the crowd that has been proven correct, yes they will probably have more sense again not to fall for this now proven unsafe technology.
It's just excess iron
Safe and effective Side effects NCSWIC NOTHING
By next year, each day they will have a jab for something.
Covid jab
If there is a jab that will stop me from becoming ill/disable/or dead & I will be in the Q.
Amazing keep up he good work
Vaccines are always safe and effective
Unbelievable BBC 📺 🗞️ 🤡🎟️🎪💉👺🎭