The Body After Drinking A Snowglobe

2020 ж. 19 Шіл.
169 802 Рет қаралды

A Dad Mistakenly Drank A Snowglobe. This Is What Happened To His Kidneys: • A Dad Mistakenly Drank...
A Man Drank 2 Liters Moonshine In 2 Hours. This Is what Happened To His Brain: • A Man Drank 2 Liters M...
The Body After Drinking 2 Gallons Coffee In 3 Hours: • The Body After 2 Gallo...
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Music by Lifeformed ► lifeformed.bandcamp.com
Music by T4N3 ► / t4n3
Additional photos courtesy Radiopaedia.org, and Wellcome Collection.
Pathology slides courtesy BMJ Case Reports, September 12 2019
Most snowglobes are just made of water, but some can contain ethylene glycol. Most of those usually don't contain enough ethylene glycol to cause damage, but keep the word "usually" in mind. A homemade snowglobe can contain concentrations of anything, which is what happened in this case.
Ethylene glycol can cause a profound high anion gap metabolic acidosis, and we'll explain the science, chemistry and physiology behind that in this episode.
References:
Delayed ethylene glycol presenting with abdominal pain and multiple cranial and peripheral neuropathies: a case report. Journal of Medical Case Reports volume 4, Article number: 220 (2010).
Multiple Cranial Nerve Deficits After Ethylene Glycol. Ann Emerg Med. 1991 Feb;20(2):208-10. pubmed.ncbi.nlm.nih.gov/1996809/
Antidotes OH that form toxic metabolites. Br J Clin Pharmacol. 2016 Mar; 81(3): 505-515. www.ncbi.nlm.nih.gov/pmc/arti...
Toxic Alcohols. N Engl J Med 2018; 378:270-280. www.nejm.org/doi/full/10.1056...
Ethylene glycol ingestion masked by concomitant ethanol ingestion. Case Reports 2012;2012:bcr1220115326. casereports.bmj.com/content/2...
Challenges in the Diagnosis of Ethylene Glycol Poisoning. Ann Clin Biochem. 2014 Mar;51(pt2):167-78. pubmed.ncbi.nlm.nih.gov/24215...
Emmett M, Narins RG. Clinical use of the anion gap. Medicine (Baltimore) 1977;56:38-54.
Uribarri J, Oh MS, Carroll HJ. D-lactic acidosis: a review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine (Baltimore) 1998;77:73-82.
Judge BS. Metabolic acidosis: differentiating the causes in the poisoned patient. Med Clin North Am 2005;89:1107-1124.
Kosten TR, O’Connor PG. Management of drug and alcohol withdrawal. N Engl J Med 2003;348:1786-1795. www.nejm.org/doi/full/10.1056...
A 49 Year Old Man With Obtundation Followed By Agitation And Acidosis. N Engl J Med 2015; 372:465-473. www.nejm.org/doi/full/10.1056...
Integration of Acid-Base And Electrolyte Disorders. N Engl J Med 2014; 371:1821-1831. www.nejm.org/doi/full/10.1056...
Calcium Kidney Stones. N Engl J Med 2010; 363:954-963. www.nejm.org/doi/full/10.1056...

Пікірлер
  • Correction! Ethanol and its related metabolites at 1:08, 2:25, 2:50 are all drawn with an extra carbon. Apologies!

    @HemeReview@HemeReview3 жыл бұрын
    • Nobody is perfect.👍Hey, it is ok. No

      @renkomon.8312@renkomon.83123 жыл бұрын
    • Thanks for pointing that out :)

      @kjhunter153@kjhunter1533 жыл бұрын
    • Thank you for the work you're doing. I know it doesn't have as much views as your main channel but as a med student I love this podcast and it sometimes helps me or makes me remember things. I really look forward to the next episode and bisous from france !

      @entonun@entonun3 жыл бұрын
    • Okay, was about to comment that xD, these things happen :)

      @KasimierLP@KasimierLP3 жыл бұрын
    • @@renkomon.8312 😂

      @sontapaa11jokulainen94@sontapaa11jokulainen943 жыл бұрын
  • "No one ever forgets their high school chemistry titration experiments" You overestimate us

    @kyetes.866@kyetes.8663 жыл бұрын
    • I mean, I remember I did them. And that our teacher was usually drunk. And he was sleeping with a biology teacher with a funny name.

      @hkr667@hkr6673 жыл бұрын
    • @@hkr667 Ok... good for you?

      @kyetes.866@kyetes.8663 жыл бұрын
    • That implies that we did titration in my class

      @AabluedragonAH@AabluedragonAH3 жыл бұрын
    • lmfao i just did my first one two weeks ago,, and not even the full experiment because my equipment was faulty

      @orangeworm@orangeworm3 жыл бұрын
    • Neh I do remember. I remember we kept making "What In Titration" memes

      @anonymyus7007@anonymyus70073 жыл бұрын
  • This stuff is so interesting even though ill never remember any of it.

    @somberlain8987@somberlain89873 жыл бұрын
    • You can if you try. We believe in you!

      @darthcuny@darthcuny3 жыл бұрын
    • LMAO SAME

      @linkedius2532@linkedius25323 жыл бұрын
    • Samee

      @carltonwilliams8390@carltonwilliams83903 жыл бұрын
    • I remember parts and thats mostly like don't do this or you will have lots of organ failure

      @Blandscorpion76@Blandscorpion763 жыл бұрын
    • You guys didn't take chemistry in High School? This is just basic stuff.

      @bahadrozturk2086@bahadrozturk20863 жыл бұрын
  • excuse-me, but where is the supposedly mandatory "mitochondria is the powerhouse of the cells" disclaimer?

    @dandan7884@dandan78843 жыл бұрын
    • Ahhh yes casually drinking a snow globe and not saying anything about it

      @OHOE1@OHOE13 жыл бұрын
  • this is the sequel to the lava lamp video that we didn't know we needed

    @richardyi8098@richardyi80983 жыл бұрын
    • Even the dad didn't need it!!!!😂

      @anishavincent4963@anishavincent49633 жыл бұрын
  • One of the liver's functions: break down toxic chemicals so they can be excreted safely. Liver: *metabolizes a relatively harmless chemical and turns it into a poison* Body: You had ONE JOB . . . (Also yes I know that the liver has WAAAAY more than one job.)

    @SaltExarch@SaltExarch3 жыл бұрын
    • Liver doesn't care if it can be voided without breaking down: it only cares that it can break it.

      @kohlrak@kohlrak Жыл бұрын
    • @@kohlrak like a tough as nails Russian boxer. He will break you or die trying.

      @koolkel00@koolkel00 Жыл бұрын
    • liver on a power trip. it just wants to break things

      @rebeccasprague5172@rebeccasprague51728 ай бұрын
    • Liver doesn't care if it makes things more or less poisonous. Liver only cares about making things more water-soluble to help the kidneys deal with them.

      @diablominero@diablominero3 ай бұрын
  • I know that this is a niche event, but could you do an episode looking at a victim of the Austrian Wine Poisoning if possible? I was always fascinated by the irony of ethanol being the cure for the antifreeze wine. Great video btw!

    @redsquadronomega7516@redsquadronomega75163 жыл бұрын
    • It's hard to look at a victim if there is none. The scandal was one because they used something what they weren't supposed to use. That's it. No one was harmed by it back then.

      @Lucy-tw4bf@Lucy-tw4bf3 жыл бұрын
    • @@Lucy-tw4bf i thought that there were tens of victims and at least 1 death attributed to it.

      @Lee-fw5bd@Lee-fw5bd3 жыл бұрын
    • @@Lucy-tw4bf There were multiple victims though?..

      @cyankoopa8111@cyankoopa81113 жыл бұрын
    • (just in case you haven't seen it yet) the moonshine video covers the competitive reaction between ethanol and methanol (or ethylene glycol, propylene glycol). Ethanol outcompetes all of them in first pass metabolism, iirc.

      @fevre_dream8542@fevre_dream85423 жыл бұрын
    • @@fevre_dream8542 this was a house episode also

      @hurpaderpp@hurpaderpp2 жыл бұрын
  • The mitochondria is the powerhouse of the cell.

    @rudolvonstroheim3898@rudolvonstroheim38983 жыл бұрын
    • And -emia means presence in blood!💖

      @maryprantephd6736@maryprantephd67363 жыл бұрын
  • I grew up surrounded by medical textbooks and listening to my dad's continuing education CDs, provided by Audio Digest. I wasn't cut out to follow in my parent's footsteps, but I never lost interest in the medical world. Aside from asking my dad for those Audio Digest disks, your channels are the single most valuable things for scratching that itch and renewing my love for the beauty of the human body. Your videos, be they about power lifting, life advice, or toxicology/anatomy have been such a wonderful thing for me over the last few years. I hope you have many happy years ahead of you, Doctor, and that you feel the joy and enthusiasm that I and so many others get when we see you've uploaded another banger. They also get me through the boring parts of my work day so thanks for that too

    @TheStoneNinja00@TheStoneNinja003 жыл бұрын
    • I hope the Doc has a chance to come back and read your comment!

      @yfa6244@yfa62443 жыл бұрын
    • Luke, mister Stone, did you go to Arcata High?

      @ramseydoon8277@ramseydoon827711 ай бұрын
  • I really like the channel name, more content from you is always good

    @synchrolord@synchrolord3 жыл бұрын
  • Every hospital needs someone who gets this stuff - a real life version of "House." If not, then they should have digital access to someone who knows these things, thereby having a consultant on hand when needed. Wonder why the EMT people didn't mention the snowglobe, not blaming them, but think how much quicker he could have been diagnosed if but for that one bit of information.

    @gaslitworldf.melissab2897@gaslitworldf.melissab28973 жыл бұрын
    • There IS no real life version of House, never will be.

      @looksirdroids9134@looksirdroids91343 жыл бұрын
    • @@looksirdroids9134 Not really. You can make one. You need to find a very high-intelligence person, and give them medical information without exposing them to hospital culture. Thus, you have someone willing to hunt zebras when they do show up. Vicodin addiction optional.

      @pentalarclikesit822@pentalarclikesit8223 жыл бұрын
    • Watson AI is made for this, it should be implemented more widely

      @Invizive@Invizive3 жыл бұрын
    • Pentalarclikesit could you explain what you mean by giving them medical information but keeping them unexposed to the culture?

      @SuperSmith@SuperSmith3 жыл бұрын
    • @@SuperSmith Think about it: People who have to spend day to day in the hospital will have both a set of standard medical teachings and defaults ("don't chase zebras" "x is usually y" "patients who think they have y usually have z" etc. and can become cynical to the same things due to peer influence. (Think people from x neighboorhood are druggies? Someone not working at that hospital, in that town has never heard of the place. The guy in charge that everyone wants to impress doesn't like x medication, or y people, or z diagnosis, people will automatically tend to go the same way, (90%) or the exact opposite (10%). People are always molded by their peers and by their sociological environment. It's simple human nature. We develop blind spots and assumptions. And if a certain group of people are missing a diagnosis, it likely falls into one of those blindspots.

      @pentalarclikesit822@pentalarclikesit8223 жыл бұрын
  • So if ethylene glycol is a positive allosteric modulator of gaba, I guess he did reduce his withdrawals to an extent... at quite a cost

    @gmrads@gmrads3 жыл бұрын
    • Allosteric modulators require orthosteric binding to exert effect. No?

      @MrZacharykgwin@MrZacharykgwin3 жыл бұрын
    • @@MrZacharykgwin - Well, yes, any modulator would have to bind to take effect.

      @ElectronFieldPulse@ElectronFieldPulse2 жыл бұрын
    • @@ElectronFieldPulse I meant in order for an allosteric modulator to exert effect it needs an orthosteric agonist, antagonist, etc... Otherwise nothing will happen if the allosteric is the only thing bound to the receptor

      @MrZacharykgwin@MrZacharykgwin2 жыл бұрын
    • @@MrZacharykgwin - Yes, you are correct, I just think that people automatically assume that given the dependent nature of allosteric modulators and how they work. Not much good on their own.

      @ElectronFieldPulse@ElectronFieldPulse2 жыл бұрын
    • @@ElectronFieldPulse indeed. The applications atleasts in drug development could be immense.

      @MrZacharykgwin@MrZacharykgwin2 жыл бұрын
  • I so wanted to study medicine. I would rise and sleep with that thought. I’m 45 and that ship has done set sail. Now, I watch your videos vicariously enjoying what you’re living. That being said, I’m one of your biggest fans 👍🏼

    @robert_costello@robert_costello3 жыл бұрын
    • @ Robert Costello: At age 45, how has the 'medicine-ship' already set sail? It still looks well-moored from here.

      @lanaharlow2515@lanaharlow25153 жыл бұрын
    • Lana Harlow Thank you for being kind, but with the kids and and all those payments due, I haven’t the time to rest... never mind going back to school. 🙏🏼 but again, your kind words made me smile 😊

      @robert_costello@robert_costello3 жыл бұрын
    • Lana Harlow the reason is because it takes 12 years total to be a doctor- 4 for premed, 4 for medical school and usually 4 years for residency (sometimes seven). They stop hiring doctors with little experience shortly after 40, and stop putting contracted doctors down for so many hours at ER's shortly after they're 55. If you're 60 and own your own private practice, they expect several decades of experience, not for you to come right out of medical school. Sure, Robert can go to school and waste hundreds of thousands of dollars to become a doctor to only never be able to pay it back due to how competitive and strenuous the job is because he'll be 57 by the time he'll actually be able to practice medicine.

      @kashinimeyo@kashinimeyo3 жыл бұрын
    • Kat Howard “I much prefer the sharpest criticism of a single intelligent person to the thoughtless approval of the masses.”- Johannes Kepler. That was masterful. Thank you for putting it in words better than I can. 🙏🏼

      @robert_costello@robert_costello3 жыл бұрын
    • could always be a pharmacist. I know folks who started late in life down that path

      @TheHerrMan@TheHerrMan3 жыл бұрын
  • Honestly watched it a couple times so I could understand it. Learning more here than 4 years of chem tbh

    @golden3008@golden30083 жыл бұрын
    • But its only been 15 minutes-

      @linkedius2532@linkedius25323 жыл бұрын
    • @@linkedius2532 2X speed bb

      @golden3008@golden30083 жыл бұрын
    • Robby P ah facts

      @linkedius2532@linkedius25323 жыл бұрын
  • "Cation" My brain: Tiny charged particles with domestic feline characteristics. 🐱

    @PurpleAmharicCoffee@PurpleAmharicCoffee3 жыл бұрын
  • this makes me feel smarter

    @noriakikakyoin7790@noriakikakyoin77903 жыл бұрын
    • Lol yeah. Poor kakyoin.... He really was a.... GEM

      @synchrolord@synchrolord3 жыл бұрын
    • @@synchrolord B) thx

      @noriakikakyoin7790@noriakikakyoin77903 жыл бұрын
  • "Take care of yourself and be-" *KZhead ad starts* "PIZZA OR SALAD"

    @ThatOneJoshy@ThatOneJoshy3 жыл бұрын
  • 14:15 "but there isnt good data out there on why this happens" this is bad. id think there is an overwhelming demand for researchers to understand and publish the inner workings of tons of different interactions within the body. yikes

    @dandan7884@dandan78843 жыл бұрын
    • It surprises me that there are actually many things we don't know in our body while we have so many paper publish every year.

      @firerocket7343@firerocket73433 жыл бұрын
    • @@firerocket7343 They are complicated problems. If you think it should be so easy, go join a lab and try to advance the knowledge base yourself! Not a negative comment, I genuinely want people to dive into the literature.

      @SelectHawk@SelectHawk3 жыл бұрын
    • It is a tribute to how complex the human body is. Research is at an all-time high, but there are still many things to be understood due to complexity, not due to the lack of an overwhelming demand.

      @epicTABmaster@epicTABmaster3 жыл бұрын
    • @@SelectHawk I did not say it should be easy. You take my comment negatively.

      @firerocket7343@firerocket73433 жыл бұрын
    • It's partly a matter of funding. Pharmacutical companies focus on research likely to produce drugs they can sell, so they don't often do this sort of basic research. That leaves funding from goverments and some privet foundations, and much of that is targeted at research likely benifit large numbers of people. I don't know how many people a year get ethylene glycol poisoning, but I doubt it's common enough to attract much intrest from potential sorces of funding

      @Ruthavecflute@Ruthavecflute3 жыл бұрын
  • I had a friend who was an alcoholic. He died of alcoholic ketoacidosis at age 35. The irony is that he was a chemist and getting a PhD in human physiology.

    @verukasault9065@verukasault90653 жыл бұрын
    • not ironc. addiction is strongly linked to stress, and medical professionals are no exception.

      @58209@582092 жыл бұрын
    • what an odd! I know a dude since i was 6 who is an avid drinker for over 30+ years. Now at Age 50, Still alive and drunker than ever! it all started to increase from casual to daily since he’s 43. As he got wealthier man.. every time i visited his office it’s all expensive liquor on table! But hey at least i can grab some🙃

      @MaseraSteve@MaseraSteve2 жыл бұрын
  • I use your videos to understand my biochemistry and the ADH example you gave before helped me a ton.

    @martin22336@martin223363 жыл бұрын
  • The channel name is genius though

    @omega_8846@omega_88463 жыл бұрын
  • 5:25 I love this fact, it's a combustion reaction basically, we breath out the CO2 and excrete the water resulted from "burning" the fat (or sugars for that matter.) This is related in my mind to the fun fact that the vast majority of the mass that makes up trees actually comes from carbon they pull from CO2 from the atmosphere, since they're made of a lot if cellulose. I love that our fat is similar, so the fat I burn off at the gym could become part of a nearby tree 😁😊

    @revenevan11@revenevan113 жыл бұрын
  • one of youtube's best

    @bearcatben4762@bearcatben47623 жыл бұрын
  • 35 years ago winerys in Austria used ethylene glycol to artificially adult the wine, some people even went to jail

    @marcelhartauer1296@marcelhartauer12963 жыл бұрын
  • This whole time I thought the liquid in snow globes was just water.

    @NintendoTransformer@NintendoTransformer3 жыл бұрын
  • Brings back memories, Dr. Bernie. Your diagnostic approach has a lot of parallels in engineering and troubleshooting engineered equipment. Nice to see people think in Medicine People who say that engineering doesn't involve "life and death" are too general. Good engineering saves lives and saves jobs and careers.

    @jamallabarge2665@jamallabarge26653 жыл бұрын
  • I really love your videos, I watch them religiously, I think you’re legit one of the best medical you tubers who genuinely does it to help spread knowledge and awareness to both the lay person and people with a medical background. I’ve been studying for my steps and you help make some concepts easy to understand and help visualize. Never stop uploading.

    @VIVI1337@VIVI13373 жыл бұрын
  • Thanks for helping me review a little bit of chem/Biochem while I’m studying for the MCAT

    @chuggacaprisunfan@chuggacaprisunfan3 жыл бұрын
  • I love the name of this channel! Truly amazing content as well.

    @danishaheer1008@danishaheer10083 жыл бұрын
  • Outstanding content doctor!

    @anthonywstanton@anthonywstanton3 жыл бұрын
    • Always had a soft spot for Edgar Allan Poe: I was born on his death date (month and day). October is my favorite month.💖

      @maryprantephd6736@maryprantephd67363 жыл бұрын
  • Love your content! Glad I found your other channel! Love learning new things!

    @trevrah@trevrah3 жыл бұрын
  • This stuff is so interesting! I love these deep dive styled videos looking into medical cases. Heck, part of me wants to study it more in depth. Keep up the great work, mate!

    @babygirl_lunaa9096@babygirl_lunaa90963 жыл бұрын
  • The organic chemistry and molecular biology jargon is so well done and really is easy to follow along with. So this is why I took those courses 😁💡!! Thank you extra study/refreshing material and a professional point of view. You rock Dr!!

    @Granulomacure@Granulomacure3 жыл бұрын
  • I love your videos! I binge watched them before every pathophysiology and pathology exam to review. They are well made and very helpful. Thank you for making such amazing videos!

    @arstor999@arstor9993 жыл бұрын
  • So, I’m crocheting a baby blanket while listening to these videos. I hope all the knowledge I listen to will be woven into the blanket, and the kid will grow up to be the next ChubbyEmu, simply by sleeping with the blanket. Because that’d be awesome. Or at the least, just a smart kid.

    @lue5776@lue57762 жыл бұрын
  • I have been enjoying your videos for quite a while but I always hoped for a "more medical" version of them, which goes further into detail, this is great!

    @simonhatterscheidt@simonhatterscheidt3 жыл бұрын
  • I love these 2nd videos to the main channel going more in depth, makes it easier to understand and is very interesting

    @denlolify@denlolify3 жыл бұрын
  • I always look forward to seeing your next video thank you for sharing your wisdom.

    @matt87635@matt876353 жыл бұрын
  • GOD bless you. you're now officially my professor and mentor!

    @BDfarsi@BDfarsi3 жыл бұрын
  • This is so easy to grasp. You are already a great teacher.

    @michellel9739@michellel97392 жыл бұрын
  • I've always been a fan of your content but I have a newfound appreciation for them [the vids] now that I'm delving into the realm of chemistry. There's a lot of shit I have trouble remembering and I realized that when I have something to actually apply that concept to-bam, I got it! that shit sticks, you know? :)) so lol, I literally use your content as study material as weird or corny as that may sound. I've realized that teaching/educating others is truly a fucking SKILL and after consuming countless lectures where it seems as though the speaker is more focused on putting material out there for their peers instead of the STUDENTS they're actually talking to..well, it just really put that into perspective for me! I think your 'audience' is something you really keep in mind judging from the format of your material, and I'm absolutely grateful for that! Thanks again, and please keep up with the great production! You're out here killin' it, my dude..entertaining aand educating:') All the best, EC

    @mackenzieonyx7586@mackenzieonyx75862 жыл бұрын
  • Glad I found this channel. I love these explanations!

    @XxPlayWithMe@XxPlayWithMe3 жыл бұрын
  • You're amazing Dr. you should develop a course for Doctors' and other health professionals on how to better explain to patients of their conditions and treatment.

    @Rayzor714@Rayzor7143 жыл бұрын
  • The ethanol diagrams in the video and the one on chubbyemu show porpanol. Ethanol should only have one 120 degree "bend". (incorrect diagram at 1:10) The glycol diagram is correct, though

    @sudochmodx3752@sudochmodx37523 жыл бұрын
    • Also the acetaldehyde...

      @johnathancorgan3994@johnathancorgan39943 жыл бұрын
    • I wish KZhead still had overlaid annotations for this reason. Factual errors need to be corrected at the source since KZhead is everyone's teacher now.

      @rm9308@rm93083 жыл бұрын
  • Back in the day I used to HATE biology. But now because of Chubby's videos I have memorized almost all the terms he has said and I would've became a doctor IF my addiction with electronic things and tech was not there. Keep up the good work!

    @ishaqahmed._@ishaqahmed._3 жыл бұрын
  • Being able to follow this video makes me feel like my first two semesters of college have been worth it :,)

    @hydroxyl5130@hydroxyl51303 жыл бұрын
  • I always wondered what the anion gap was. I went through kidney failure and was on dialysis for a year before I got a kidney transplant. I always liked to look up and learn what the different blood tests meant and I always had a high anion gap. Now I know the chemistry of why I had metabolic acidosis. Really interesting thank you!

    @ZomgItsZaon@ZomgItsZaon3 жыл бұрын
    • I hope that you're doing well.

      @ramseydoon8277@ramseydoon827711 ай бұрын
    • @@ramseydoon8277 Thank you for checking on me. Yes I am still doing well, going 3 years strong on my transplant now! I hope you are doing well too!

      @ZomgItsZaon@ZomgItsZaon11 ай бұрын
  • Your videos are so amazing . Medicine is so intresting and there is so much to learn everyday , I am actually considering going to a Med University because i enjoy learning anatomy and everything related to the human body . You are doing a great job , keep up the good work :)

    @Cozmaaa69@Cozmaaa693 жыл бұрын
  • Thank you. I like this presentation format.

    @kreynolds1123@kreynolds11233 жыл бұрын
  • Wow, I've been watching your other channel for a while and didn't realize you had this one too. Guess I should sub to this one too haha!

    @mountainking1166@mountainking11663 жыл бұрын
  • Moral of these vids. Ima make sure i Always have lots of Ethanol in my system so i cant get poisoned.

    @garrysekelli6776@garrysekelli67763 жыл бұрын
  • I am shocked to hear this patient made it after such a trauma to his kidneys. Starting this, I was afraid he would succumb to sepsis, from kidney failure or brain death from poisoning and coma. Alcoholism is a sad and scary disease to think the lengths one would go to ingesting such a toxic substance. I wish this channel was around when I was studying for my State Conference Funeral Director/Embalmer Board Exams, and in school. I am not practicing now due to chronic illness, but still like to keep up with the medical terminology and anatomy in all aspects. The human body is amazing.

    @Sogonrei@Sogonrei3 жыл бұрын
  • Oh I didnt know the yt heme review videos had visualizations of the content. Just came from the audio exclusive ep!

    @user-zi4sz8kj1g@user-zi4sz8kj1g3 жыл бұрын
  • I honestly like these videos where you explain why ingesting X material is bad, in detail. I always look forward to them. By the way, have you ever had a patient that drank gasoline/diesel/some other petrochem product? If you have, I'm wondering if you would be willing to do a video about it?

    @davidc9640@davidc96403 жыл бұрын
  • after watching so much forensic files 20 years ago in college, as soon as you mentioned crystals in the kidneys I said to myself "its ethylene glycol!!!"

    @megsley@megsley2 жыл бұрын
  • This level of knowledge on body chemistry processes has always been the favorite part of your videos. Is this something a normal MD learns in med school though at this depth? Or is it something you specialize in?

    @locusf2@locusf23 жыл бұрын
    • Technically, every MD should know that, at least in Poland, where I study. We have biochemistry for 2 semesters and I'm also pretty sure, that these mechanisms are mentioned on patophysiology. However, after talking to many doctors while on my clinical activities I have realised, that not many MDs remember this kind of stuff - at best, they know cause and consequence of certain processes, like for example glycole ingestion, but most of them think, that knowing the pathway that leads to the consequence is unnecessary. And without repetition, there's no way to remember something that you learned on second year of med school.

      @miekisssz@miekisssz2 жыл бұрын
  • This video's so high-IQ, it's making my head hurt.

    @NA-hb1lh@NA-hb1lh3 жыл бұрын
    • No, it's just a sign that maybe you should study more.

      @kashinimeyo@kashinimeyo3 жыл бұрын
    • ​@@kashinimeyo Allow me to point out for you that this comment is based on a meme format from the anime "Dr. Stone", since you apparently aren't aware of that. With that being said, have a nice day.

      @NA-hb1lh@NA-hb1lh3 жыл бұрын
    • @@kashinimeyo nah bro we just dumb 😔

      @hugskitten6100@hugskitten61003 жыл бұрын
    • @@White742 Yes, cause chemistry is obviously where it's really at :P

      @jayhill2193@jayhill21933 жыл бұрын
  • great vid man. learned quite a bit

    @leonchen452@leonchen4523 жыл бұрын
  • I think the ethanol structure is incorrect. It looks like propanol

    @Everthingyouwannknow@Everthingyouwannknow3 жыл бұрын
    • He mentioned it was a mistake...on the other hand, oxalate can bind to more than just one calcium ion...the multiple calcium-oxalate complexes form a lattice characteristic of the crystals that form in the kidneys

      @brandonveltri2825@brandonveltri28253 жыл бұрын
    • @@brandonveltri2825 Well yes and no. If you take an individual oxalate molecule, it would bind to one calcium, but a crystal is of course a microscopic megastructure where the kations and anions are strictly organized in a grid, therefore distributing the charges not just between two counterparts, but every surrounding particles.

      @jayhill2193@jayhill21933 жыл бұрын
    • JayHill the two carboxylates from one oxalate can bind to at least 2 calcium ions as bidentate coordination complexes...technically it can stabilize 4 Ca2+ ions between itself and another oxalate

      @brandonveltri2825@brandonveltri28253 жыл бұрын
  • Med school couldn't teach me Anion gap properly and here we are in KZhead academy learning medicine like it's actually science and not just facts that you gotta memorize, thanks to creators like you, so thank you !🙏🏼😅

    @hadihoseinzadehsalaleh269@hadihoseinzadehsalaleh2693 жыл бұрын
  • Recently there was several cases of ethylene glycol intoxication in Brazil due to problems related to the production of a certain beer brand. Something related to the anti-freeze machine.

    @asCaio@asCaio3 жыл бұрын
  • Way back I studied Chemistry and Biology, but due to life circumstances at the time, I completely changed my career path. I wasn't bad at science, but my interest in chem/bio withered. Your videos makes me wonder where my life would have taken me if I stayed in science :) I'm very good at what I do now, but your explanations bring me back :)

    @Deedee0007@Deedee00073 жыл бұрын
  • Come to learn chemistry here😀

    @Sundaymorning12@Sundaymorning123 жыл бұрын
  • Can methanol poisoning also be treated by giving ethonal? Does the body have a higher affinity for ethonal than methanol like it does ethylene glycol?

    @golden3008@golden30083 жыл бұрын
    • yes!

      @HemeReview@HemeReview3 жыл бұрын
    • @@HemeReview When I was a young corrections officer in Michigan, we had about 15 prisoners from Jackson prison to our medical unit who had consumed methanol. (stolen copy fluid) We had them locked in cells and were giving them double shots of vodka every half hour, even if we had to wake them up, to help their bodies to eliminate the methanol. At first it was a big party, here's the prison giving them vodka. About two hours later, the whole medical unit smells like puke and the only prisoners who weren't refusing to drink more were the old heads who knew better. They talked most of the others to keep drinking. Of the 15 we had transferred to us, two went blind. All of them lived.

      @groermaik@groermaik3 жыл бұрын
  • Acid-base relationships, ions and anion gap, metabolic and respiratory acidosis--Knowledge is power. Thx, Dr Bernard.😊💖

    @maryprantephd6736@maryprantephd67363 жыл бұрын
  • If I'm recalling correctly, oxalic acid is the component of spinach that gives it the strange mouth feel. Oxalic acid in the spinach reacts with calcium ions on your tongue/teeth and in saliva, giving it the "fuzzy" feeling as it forms micro crystals.

    @felixu95@felixu953 жыл бұрын
  • Good gravy! You are one smart fella! Hubby and I drink decay tea everyday, obviously we haven't drank to much, but what is wrong with tea and how much is too much?

    @laurieg5899@laurieg58993 жыл бұрын
  • It is the 100th time I learn the Acidosis-Alcalosis stuff, and it will be the 100th time I'll totally forget what it is.

    @MrYondaime1995@MrYondaime19953 жыл бұрын
  • About oxalate, there's ongoing debate about whether to eat oxalate rich food (like spinach) with calcium rich food (cheese/ tofu). Some say that the two when eaten together accelerates the body's excretion of the calcium-oxalate salt, while some say that this combination accelerates the formation of kidney stones. What's your opinion on this?

    @cassiel6217@cassiel62173 жыл бұрын
  • I love your hair, it's so pretty

    @twintyara6330@twintyara63303 жыл бұрын
  • I’d never fully understood the anion gap until this video. Thank you

    @Meemsnt@Meemsnt2 жыл бұрын
  • Such an educational content! It's always a nice complement to med school. I would love to bring that format to Medical Physiology and Applied Physiological Reasoning classes at my University. Could you help me out?

    @JoaoPedro-eb6kh@JoaoPedro-eb6kh3 жыл бұрын
  • Dayum I like your hair like this looks 👌🏻🔥

    @5urg3x@5urg3x3 жыл бұрын
  • I like how the further on in education I get, the more relevant my chemistry knowledge becomes in these videos

    @simonepradhan5023@simonepradhan502311 ай бұрын
  • This is very interesting can’t wait for the next episode

    @Jackal-xc9sw@Jackal-xc9sw3 жыл бұрын
  • I wish I had your video's while I was failing chemistry in highschool 😓

    @lieselotl6319@lieselotl63193 жыл бұрын
  • I think it would be cool if you could make a follow-up video on the current state of research on potential treatments for COVID-19. It seems like there is a LOT of conflicting research on a variety of different drugs, including hydroxychloroquine and azithromycin, and it is near impossible to muddle through it all as someone with a high school-level background in biology.

    @genericereal@genericereal3 жыл бұрын
  • I enjoy these more informative videos!

    @iamharper@iamharper3 жыл бұрын
  • I am so jealous at the level of your intelligence. That being said, please take me to your leader ✌🏼

    @robert_costello@robert_costello3 жыл бұрын
  • I'm a medical lab student in Canada and we learned MUDPILES this year as causes of high anion gap (something we see a lot). GOLDMARK was taught as an additional acronym but it never appears on exams, its always MUDPILES. I had no idea GOLDMARK was newer/better.

    @lucinoide-2174@lucinoide-21743 жыл бұрын
  • I’m finally using my languishing organic chemistry knowledge 🙏🏻 I noticed some goofs but I’m not gonna fret.

    @KateCarew@KateCarew3 жыл бұрын
  • I remember reading about an ethlyene glycol poisoning that caused the calcium oxolate crystals to form in the brain. Pretty terrifying, although we haven't actually covered diols in detail in Organic Chemistry yet.

    @petalmagic8391@petalmagic83913 жыл бұрын
  • Never knew you had a second channel

    @katevogel4773@katevogel47733 жыл бұрын
  • My brain couldn't process majority of the content but that was great.

    @MrDhanesh2nair@MrDhanesh2nair3 жыл бұрын
  • 3:10 This song is amazing.

    @FluttershyIsAGoddess@FluttershyIsAGoddess2 жыл бұрын
  • HI!! Would it be possible for you to do a video looking into and explaining the MTHFR gene mutation and it’s effects/links to thyroid and kidney issues? My family is trying to get tested, as we nearly all have clear symptoms or signs of the mutation, but our family Dr. claims there’s no reason to. :/ (Thank you!)

    @eephullothere9192@eephullothere91922 жыл бұрын
  • Your channel is better chemistry class than HS and university.

    @willrouse2351@willrouse23514 ай бұрын
  • Can I simplify it to , when our body produces acids it eats up HCO3-(their H+ ) leaving behind their anions so producing an anion gap as well as lowering bicarbonate?

    @mickeysingh7443@mickeysingh74433 жыл бұрын
  • So Dr. Hsu’s clickbaity content is brilliantly thorough, way more than a lot of pop science stuff - and then I find out he does a parallel series without the sensational presentation. This guy.

    @wabznasm9660@wabznasm96603 жыл бұрын
  • Chubbyemu: eli5 Heme review: Eli doctor

    @xorowl1584@xorowl15843 жыл бұрын
  • Thank you

    @hot91526@hot915263 жыл бұрын
  • Thanks!

    @redraider7876@redraider78762 жыл бұрын
    • Thank you!

      @HemeReview@HemeReview2 жыл бұрын
    • Never before have I seen a donation on KZhead outside of a live stream

      @U20E0@U20E02 жыл бұрын
  • Ooh, ever thought about doing a video on the Elixir Sulfanilamide incident that led to the FDA getting more power to make medications safe? Or would that be an over saturation of alcohol group related videos?

    @darksorceressharuko@darksorceressharuko3 жыл бұрын
  • I love your videos!! Oh yeah yeah

    @karlodomijanold@karlodomijanold2 жыл бұрын
  • Confused at 9:25-10:00.. why the outcomes (alkalosis vs acidosis) are different when anion level decrease through vomit vs with diuretic..?

    @erdenemashbat3379@erdenemashbat33793 жыл бұрын
  • I unironically love that he breaks down and explains the Latin roots of the big confusing medical words and he does it every time, because especially when you binge watch his videos, you hear it over and over until it sticks and you remember what the bits mean!! It goes from "I have no clue what that means", To, "Hey that sounds familiar" To, "GLYCE!! THAT MEANS SUGAR!! AHA! can't remember what the rest means tho" To "HYPOGLYCEMIA! HYPO MEANS LOW! GLYCE!! THAT MEANS SUGAR!! EMIA!! PRESENCE IN BLOOD!!" HYPOGLYCEMIA, LOW AMOUNT OF SUGAR IN BLOOD!!" BOOM IVE CRACKED IT I CAN EXPLAIN SOME OF THE WORDS IN A MEDICINE COMMERCIAL TO MY FRIENDS!! and then I shatter a glass bottle on the ground, put on my cool dude shades and lean back in a chair with my feet up and from somewhere you can hear some sick guitar shredding in the background.

    @koolkel00@koolkel00 Жыл бұрын
  • I remember reading about how ethanol effects the human body and how it is specifically metabolized in to acetaldehyde and acetate in the liver and then how it effects the gaba neurotransmitters in the human body to cause the effects that it does and it was interesting seeing how and why other alcohols are metabolized this way. To bad I don't really have much real world use for this information...

    @nice8D@nice8D3 жыл бұрын
  • Can you explain the vapor pressure function and osmolal gap? Why is vapor pressure relevant?

    @ralstonwithanr@ralstonwithanr3 жыл бұрын
  • I really want to study medicine, but my parents want me to work right away when I finish high school this year. I'm so fascinated by the human body though and I love these kind of video's 🙂

    @s-9889@s-98893 жыл бұрын
    • Don't listen to your patents, chase your dreams!

      @jeffreyvega7260@jeffreyvega72603 жыл бұрын
    • What did you end up doing?

      @Maros554@Maros5548 ай бұрын
    • @@Maros554 I was lucky enough to get accepted in the first med school I applied to on the first try. Just started my second year of med school! Have not regretted it once😁

      @s-9889@s-98898 ай бұрын
  • Too many peanuts? As someone who has been known to get though a lot of peanuts at a sitting (so over the cause of a day whilst studying) how much is a lot?

    @ganrimmonim@ganrimmonim3 жыл бұрын
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