How this disease changes the shape of your cells - Amber M. Yates
Dig into the science of how a single genetic mutation alters the structure of hemoglobin and leads to sickle-cell disease.
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What shape are your cells? Squishy cylinders? Jagged zig-zags? You might not spend a lot of time thinking about the bodies of these building blocks, but microscopically, small variations can have huge consequences. And while some adaptations change these shapes for the better, others can spark debilitating complications. Amber Yates dives into the science of the malignant sickle-cell mutation.
Lesson by Amber M. Yates, directed by Axon Animation LLC.
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Damn your right
he can also make weird voices
Are you saying that TED-Ed is Johnny Sins ?
Just like Johnny Sins, huh?
@@maribelabanador206 what about their left?
I have Sickle Cell Disease, SC diagnosis ( yes, there are different diagnoses of Sickle Cell Disease). I’m so glad this video exists because it spreads much needed awareness. Thank you so much, Ted-Ed
foreveryvette omg thank you for pointing that out 👏
My best wishes to you. I am sorry you have sickle cell disease. But you are brave for going through it all!
Well, now I wish they'd make a video covering that...
FOREVER YVETTA I have sickle cell SC as well I've actually have had a stroke cuz of it thank you for sharing btw especially that there r different types of sickle cell
Well,we hope you're doing well,stay strong! (Idk if you say that only to cancer I'm Romanian but I still like to say it)
Cells At Work would be a lot different if the Red Blood Cell was sickle shaped
@LagiNaLangAko23 That's interesting, first time I heard about that
I don't watch KZhead videos, but I hear these blood cells can be sticky.
Ironically she was a sickle cell lol
She’s not a sickle cell because then there should be more cells like her. She’s just an anime cliche.
@@MysticOceanDollies just look at her hair, one of it sticks out like a sickle.
As a person with Sickle Cell Disease, I just wanted to say thank you 🙏🏿 Love your videos
I’m so sorry you have this🥺 I can’t imagine what life is like living in huge pain. I’m not sure how constant the lack of oxygen to certain tissues occurs but I hope the episodes are at least infrequent.
😭😭😭😭😭😭😭😭😭😭😭😭😭😭
I hope you're coping well. Sending a prayer your way.
I have it too, it sucks
Naira Bee thanks for understanding
Thank you for spreading awareness of Sickle Cell, it's not very known where I live.
I just found out a few weeks ago I have the sickle-cell trait. Long story short, they looked into it because periodically throughout my life I've gotten anemic and was (mis)diagnosed with thalassemia as a child. Only reason why I even found out about it was because I got pregnant, and when you get pregnant, they test you for literally everything. At first I got offended, as my normal self wasn't important enough to test/look into, but my pregnant self was important enough to care about. Almost like all I've ever been good for was to be a vessel/incubator. Then I realized it doesn't matter and that I'm glad I found out anyway, as now I know the baby might also get the trait, but won't get the disease since her father does not carry the trait or the disease.
Mothers can not pass on this disease to their off springs?
@@vikrraal the trait is when only one parent has the disease so its not as bad
You should have gotten tested for Sickle Cell trait before getting pregnant. That is the responsible thing to do.
@@jimmymackinnon8474 she literally got misdiagnosed for thalassemia. There was no reason to suddenly test for SC disease.
@@bananana6380 Yeah you are right.
Another awesome video to learn about sickle disease.. Thanks for the video..🙏
I know right these animations and voice overs are the best way to learn just about anything :)
I wish there's something on the wall street crash
Hi there brother, you are right
Hey think of the bright side U have more immunity to malaria
I suffer from sickle cell and I appreciate this video hopefully it raises more awareness
DaX same here blood bro
Not sure about you but whenever I tell someone I have sickle cell they go and research it and end up knowing more about it than me
Darion W. Beats I wish that was the case with me but most of the time people find out when I tell them after they rudely ask why my eyes are yellow after the awkward “ah I’m sorry” they just act as if nothing happened at least if they had heard before previously like in this video they’d have previous knowledge to make sense of it and connect it to.
@@lazypanther7402 haha lol hope you get better did you watch the vid is genetic so its a part of you but i get what your saying its just a nice to say hope you ll get better
Allah help you
I dont even know there are disease that change our cell shapes. Thanks Ted-Ed!
And hopefully , neither you nor your loved ones has to experience the effect of that change. stay safe.
The animation is incredible and clearly narrated. I really love how they "draw" the blood cells & other assets with a very detail design (like putting the shadow to make the textural-effect and make it look more real). Yeah again, another amazing video & narration from Ted Ed!
I read the title as "How this dishes change the shapes of your cell".
Lay off the weed for a while fam.
@Ervin Dahlén so you're saying do drugs not dishes ?
lol
Thank you sooo much for spreading awareness about this disease. My daughters suffers from this disease. A note to any who read: Many even in the medical community dont truly learn or understand this disease. This results in so much mistreatment of those affected. The pain many endure both literally and psychologically is unspeakable. The next step we need is a cure. Please support efforts to cure this disease. ❤
It's so hard to cure.
I also have sickle cell anemia and I’m always looking to learn more about my illness. Videos like these not only help sickle cell patients learn but also help raise awareness and teach others about our illness. Thank you so much Ted-Ed
Do you often need blood transfusions?
My dad had Sickle cell SS he suffered all his life from it. He passed away 2 months ago when a stroke combined with the symptoms happened. I have Sickle cell traits inherited from my dad which means the symptoms are way less severe but still painful at times. Thank you for this video and for spreading the knowledge of Sickle cell
Just one request bro please please please no matter what but never get a child before test that your partner is not has scd or trait. My humble request.
@@Ironman-BBthere is a way that you can have a baby without the disease because you can screen their DNA to see if they have the disease if they do you can possibly have that gene removed that causes the disease
This is fascinating! I had no idea of the origins relating to malaria! It's sort of reassuring that it has it's benefits and isn't entirely a hindering disease but a legitimate, unwittingly innovative human adaptation. I'm glad to understand it a little more.
Actually it doesn't work exactly that way, the sickle cell mutation didn't originate from a malaria infection. It was actually just a random tiny mutation that happened to some ancient human that coincidentally gave him the evolutionary advantage against malaria. Then that person went and had offsprings carrying the mutation in their dna and the rest is history
@@Ordinary_Mortal right
@@Ordinary_Mortal no it was to fight malaria. There’s a reason many west/central Africans and their descendants have it
Ah, as a medical student, I absolutely loved this.
I've learned about this in 6th grade. Totally forgot about it untill now.
You must've gone to a good school
@@all_is_dust_ I live in Germany and here you can choose a subject that will be added to your main subjects. Evryones regular main subjects: German, Math and English I choose NB = Nature sciences and Biology. As in Biology, chemistry and physics. We were talking about different types of diseases, i think. Somehow the topic went to this, i think it was because we then started talking about an illness that people with sickle cell disease are immune against. Our Teacher decieded to add it to our "learn" plan, squeezing it next too Malaria , and including it in the class test. It wasn't ever brought up after that though.
I’m in 6th and learned this not long ago
Ani stays sarcastic your lucky. In the USA, they force everyone to do the Same thing, and if you don’t show up at school because you don’t like it, even for 2 weeks along the course of a year, child services will come and take/ force you back to school.
Lemon Lime American school is not the best. I experience it 5/7
Ted-ed never disappoints...
Damn, so interesting that the mutation was actually advantageous at first.
Still is, so long as you are a carrier of the disease.
@@Ytremz I know. I was just trying to be concise
Yes if you are a carrier it means one parent has the disease or trait and the other doesnt. Both parents that have the disease or trait will have offsprings that will inherit the disease. Isn’t science and genes fascinating,
if both parents have the trait the child doesnt always develope the disease, only about 25% of the time. This has to do with the fact that both parents still have one copy of the dominant gene that they could potentially pass down to their offspring. Sickle cell disease is only expressed when both parents pass down the recessive copy of the gene. There is also a 25% chance that their child would not be a carrier of the sickle cell trait either.
My exam is tomorrow and this is in the syllabus. Perfect upload timing!
Good luck on your exam!
How did you do? Read this when you are at home!
Gl
This is bloody terrifying
Badum no.
Pun intended
and it ain't fun to live with either. imagine that ...
I remember talking to some classmates a few weeks ago. We were talking about how we definitely need to get rid of malaria to cure SCD. If the sickle cell shape was an evolutionary response to malaria, it makes sense that we would also need to get rid of it to prevent SCD from coming back. On that note, SCD treatment has been improving greatly and it's really cool seeing people be more aware of how terrible this disease can be.
@Where's the hen? which would be a bad idea because they serve as an important part of the food web
@Where's the hen?no mosquitos, no birds. No birds, even more bugs of all kind. More bugs, less food.
@Where's the hen? mosquitos dont kill us, the disease does. mosquitos are important because they are eated by various other animals
@Where's the hen? however the increase in bugs is an effect of bird populations decreasing. By the time the birds recieve the new source of food damage in agriculture has already been done. Not to mention male mosquitos are pollinators so there's that too
@Where's the hen? Well for one, we are only able to domesticate food for ourselves because the environment exists. We may not rely on it, but every other animal in existence does. If we do not preserve it then they will begin to compete with us, i.e. bears being spotted closer and closer to civilization in recent years. Also nothing ""entirely relies" on mosquitos is not a valid reason. If we remove 10% of food for humans, that's 10% of people who will starve. If we remove 10% of food for birds, 10% of pollination for plants, that is 10% less birds that can be sustained and 10% less plants that can be grown.
My mum and my sister have this and now I understand it thx
I hope the best for them.
Thx
@@johnfadare8279 sorry but, how does this hallen, how do they get the disease?
Basically you can have a trait from it where someone else in your family has it and they pass on a trait of it to you. If you have the trait it’s ok but if you have a child with someone else with the trait the baby will have some disabilities.
so does your dad also have this
You don't know how good i felt when i saw that there was a video about this disease. Because i feel like people don't talk about it as much as they should.
Thank you for this vid! I have the SS mutation (the worse kind) and I found as I got older the more I really understood what was happening to me because of research, good docs and videos like this. I’m hoping we find a cure soon!
Thanks Ted-Ed for uploading this video, I understand this disease so much better now, I didn't know it affects people in so many ways, in Nigeria we have a lot of sickle-cell affected people and some of my family even carry the trait, although it is weird that this video didn't explain the idea of AA, AS and SS genotypes, that is standard fare for any lecture on sickle cell in Nigeria. I still enjoyed it immensely though. To reduce the chances of having a child with sickle cell anaemia in Nigeria you are encouraged to find out the genotype of your partner before marrying, such that an AS should marry only AA or SS should marry only AA but AA can marry either AA, AS or SS.
I started talking to an old friend from high school recently, she has sickle cell disease. She is the kindest soul I've ever met. I wish I could hold her when she's in pain because of it... I hope every day that our research and development will one day make the disease no longer a worry for her and everyone else affected. Love you all.
The animation of how normal RBC changes into a sickled one is just awesome. Great work.
As someone with this disease I appreciate a good informative video. This makes it that much easier to educate people who are apart of our lives.
My brother has this and is always in and out of hospitals. Thank you for spreading much needed awareness ❤️
Both of my cousins have this, I hope one day a treatment comes out that makes life easier for them, they have it really bad...
Sickle cell is so scary on the first sight of it. But knowing that there are ways to cure it or at least decrease the severity is very relieving. Thank you Ted ed
I have Sickle Cell disease, thank you for making this great video ♥️
Hi, Ghada.. Can you tell me how do you manage your day to today life with this disease and precautions that you take or any other information that you are comfortable to share regarding this ? My cousin has this disease and he's very depressed after he learned about his condition. Some extra information will help him. Thank you
@@vikrraal Hey. first of all, I never never miss my Hydroxyurea, each day I have to take it so I can reduce the number of crisis episodes. And I take lots of other meds like Warfarin cuz I had a brain stroke, Folic acid ... etc. I drink lots of water, try to not exhaust myself physically or emotionally cuz I do get a crisis when I cry or get upset. He will be able to live a normal life he just has to take really good care of himself cuz the crisis pain is not easy.
If I understood the video, most of those that suffer from the illness are Africans, so I was wondering if you were African yourself or or do you have a parent of African origins ?
@@manamanaman No, I'm Yemeni
@@manamanaman its in countries where malaria develops which is in tropical regions so Africa and other countries with a hot climate
Me: “Thats a red blood cell” My brain: EAT IT
U can’t eat a red blood cell cuz ur not a vampire
wait i felt the same 👀
I have Sickle beta thalassemia disease .. which is both scd and thalassemia genes! , I'm so thrilled to see your video especially while we live in a world where medical researchers are NOT paying attention to us and NOT doing their best to find a cure . Thank you Ted-Ed❤
I have a rare blood type which is specifically used for sickle cell patients, its nice knowing my blood isnt being wasted and actually helping people
I really like this video format (the animations with live footage cuts) - please make more like this.
It feels bad how much pain is gone through daily with this disease. God bless you all.
Thank you for covering this. I have this condition
Thank you so much Ted- Ed for doing the research and actually looking into this and spreading an awareness of this. I have Sickle Cell Anemia and not many people know much about it. Thank you so much for this video Ted-Ed.
You have explained this with excellence . Great work!
2:38 I feel bad for whoever had to let that mosquito bite them for that long...
has heard and learn about sickle cell disease back when I was high school or something, I imagine that the bowl shape of the red blood cell carry a pearl like shape oxygen inside, so when a person have a sickle disease, their bowl shape became a plate, make it harder to safely carry the pearl, never knew that the truth is something like this. certainly entertaining and educational! Thank you TED-Ed
People with sickle cells: **happy that awareness is spread about our disease* People without sickle cells: **make communism and sickle mode jokes* **Insert suprised pikachu meme*
How can you make a communism joke about it if not everyone has sickle cell disease?
*im on sickle mode*
Darion Beats I have sickle cell and I found this very funny. 😂 sometimes it’s good to laugh about the serious stuff in life
r/fellowkids lol
Fr I have sickle cell and I was playing with my friends and I got angry and they said he’s going Sickle mode
Gets saved from Sickle-Cell Disease Gets Malaria
oof
*suprised pikachu face *
Another great video and animation
Thank you for this video! I have sickle cell and awareness is scarce, it’s finally being talked about on a international scale
My sister has sickle cell and I’ve never looked into cause I was so young, thank you for informing me!
amazing facts!!!I have never known about that.Thanks Ted!!
What an awesome video as always. I've always thought that a red blood cell only had one haemoglobin and only carried 4 oxygen molecules. After watching this, I've got a clearer picture now. Thanks~
*Thank you for talking about Sickle Cell.* Awareness helps people understand and be better.
I have sick cell and thx for spreading awareness it's very hard to explain excruciating pain when there are no physical problems outside the body.
Thank you ted Ed! You teach me more than school
Malaria: Sickle Cells: *I'm about to end this man's whole career.*
Best description of Sickle Cell I've heard. Great video
Thanks for raising awareness Ted-ED. Sickle cell diseased (SS homozygous) 🙋🏾 from India 🇮🇳.
Yeah, I've been waiting this so long! Now plzz make a cystic fibrosis one!
Very informative and explained in a simple to understand video with great supporting animation. My one Math skill at a time videos are inspired by TED-Ed and are simple to understand for everyone. Much Love 😍🤗
As always Ted Ed blows me away with their fantastic videos!
I have sickle cell anemia, thank you for this video ❤❤❤
"Today most people with sickle cell disease can trace their ancestry to a country where Malaria is endemic-..." Or where it was historically endemic until the last four hundred years or so. Parts of Italy, France, Greece, and Spain mostly.
Rest in peace P 🙏
I like how you combined animation with real footage.(I suggested that in an earlier episode about an animal)
What's awesome is that I used to watch Ted-Ed since I was about 5. I still watch it and probably always will! Often I didn't really know much about stuff like these at all, so no wonder I found them fascinating at a young age.
Fascinating! Sickle cell disease is the one we usually think of. I've always thought crenation of cells was pretty interesting. Maybe I'll do a piece on my channel of how these things appear postmortem!
Thank you for making this video, it makes explaining my condition easier.
Ted Ed makes learning way more fun than just reading a book, this is a really great video :)
Thanks I needed this for my biology test!!! I love your channel
I'm a med student and I just saw a kid with this disease. Like, about half an hour ago.
River Tree how was the kid?
Oh poor kid. I hope their treatment goes well.
Next thing you know, some people on the internet might would make fun of him for having a disease. Dark humor at its finest, and I focus too much on that stuff.
Joned me for the treatment of sickcle cell, stroke,autism, cerebral palsy and is curative with plant stem cellttps://chat.whatsapp.com/GuNgYEraQlqEj5FvTEe1sy
I read it as "I'm a mad student" ...sorry
this is very interesting due to the fact that I have the disease and I know how it feels to be a sickler.
this post was made by the sickler gang
Thank you. I learned a lot more about sickle cell anemia today.
I haven't learned heard this disease but now I know Another Awesome Video TED-Ed
here i am watching with sickle cell anemia
Evette Andrea same here
Ted-Ed educating the masses yet again
Love🥰 to all those that deal with this!! Hurt my heart and that feeling will never be enough to do anything, so so so so sorry 😭😭 !!
Beautiful animations !!
I'M LEARNING ABOUT THIS IN BIO!!!
I'm in love with the shape of you(r blood cells)
Hi
That's erythrocyte-ist.
That cat though
The animations are awesome!
I have the trait so I don't really get symptoms but i am glad that this is being shown and shared to thoes who may not know what sickle cell is and are now learning about it.
Very informative plus entertaining narration. Thumbs up
"Beneficial mutation". It's as beneficial as sawing off your foot to prevent foot fungus
Thankyou so much for showing awarness to Sickle cell!!!!
I read about this disease in my Chemistry book and learned a little about it in school Thanks to this video, it helped me learn more about it
Hataraku Saibou comments are coming. Love your videos TED-ED btw.
I already expect this comment when read the title
At least it helps prevent malaria.
Lol not always. I have it and have had malaria twice in the past. Got scammed at birth man.
Thank you! This _NEEDS_ to be talked about more. You only hear and see other diseases mentioned... 😒 Those of us wit SC go thru sooooooo much, yall jus don't kno. Not to mention the severe & dire pain crisis (Daily for me) we have to endure as well. So all of that you complaining about, we have to deal wit it all too + more. Please count your blessings and just be thankful you're not having to live constantly in this hellish nightmare. 😔
Finally! I asked about this a couple of months back. Awesome
So you're telling me, that if I have SCDm then I can walk around where there is tons of Malaria, and I can just walk around like a god? Damn.
i used to feel like that but lemme tell you its much more preferable to be susceptible to malaria than to live a life with sickle cell. i'd trade you in a goddamn HEARTBEAT
Is it possible to have Hammer and sickle cell?
only for true soviets
Amazing video as always!!
Thanks TED-Ed! Another great video )
On the plus side your immune to malaria
No one: Not even a single soul: **Sings USSR national anthem**
This video is very important and full of knowledge
Thanks a lot for such knowledgeable video...
1:16 *S T I C K I E R*
_HOW DOES THIS DISEASE CAN CHANGE YOUR CELLS..._ *Osmosis Jones:* Good question...
*white blood cell with binoculars* also a good question....
Love the animation thanks ted ed for high quality learning
Very nice visualisation!